Beilstein J. Org. Chem.2018,14, 506–514, doi:10.3762/bjoc.14.36
subsequent treatment with NaN3 in aqueous medium to give azido oxazoles in good selectivity. Processintegration enabled the synthesis of this useful moiety in short overall residence times (7 to 9 min) and in good overall yields.
Keywords: azirines; continuous flow; heterocycles; oxazoles; process
integration; vinyl azides; Introduction
Oxazoles are an important class of five-membered aromatic heterocycles containing one oxygen and one nitrogen atom in their structures. The oxazole moiety is relatively stable and is found widely in nature [1][2][3]. Naturally occurring oxazoles include compounds with
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Graphical Abstract
Figure 1:
Examples of naturally occurring oxazoles (a); some drugs containing oxazole as the active moiety (b...